Leiden, The Netherlands, December 18, 2017, – ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company, and Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced a clinical collaboration to advance ISA101, an immunotherapy targeting human papillomavirus type 16 (HPV16)-induced cancer, in combination with cemiplimab (REGN2810), a PD-1 (programmed cell death protein 1) antibody. Regeneron and ISA will jointly fund and conduct clinical trials of the combination treatment in cervical cancer and head-and-neck cancer.
Expression of HPV oncoproteins contributes to the development of cervical and head-and-neck cancers, and approximately 55 percent of cervical cancers and over 60 percent of head-and-neck cancers are HPV16 positive.
-Ceremony Conventio Medicinae held at University Medical Center
Leiden, The Netherlands, October 26, 2017 – ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company, today announced that its Chief Scientific Officer, Prof. Cornelis Melief, has received an honorary doctorate from the University Medical Center of Johannes Gutenberg University Mainz, Germany. The honorary doctorate was awarded during a festive ceremony in Mainz on October 25, 2017.
Prof. Melief was recognized for his lifetime achievements as a pioneer in tumor immunology and his special merits regarding immunological research in Mainz.
“It is a special honor for me to award Prof. Cornelis Melief with the honorary doctorate of
Please find below a link to an interview taken during ESMO in Madrid with Dr Bonnie Glisson on the combination trial of ISA101 and Nivolumab (aPD1) in SCCHN patients run at MD Anderson Cancer Center:
– Incurable HPV16+ solid tumors treated with therapeutic cancer vaccine plus checkpoint inhibitor
Leiden, The Netherlands, September 4, 2017 – ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company, today announced the presentation of the results of a clinical Phase II trial initiated by MD Anderson Cancer Center in collaboration with ISA and Bristol-Myers Squibb (NCT02426892) at ESMO 2017 (September 8-12, 2017, Madrid, Spain). In the trial, cancer patients with HPV16+ incurable solid tumors received a combination of ISA’s synthetic long-peptide (SLP) HPV-16 vaccine ISA101 and nivolumab, a monoclonal antibody acting as a PD-1 checkpoint inhibitor.
-Phase I/II trial shows significant responses of HPV16-positive patients with late-stage cervical cancer
Leiden, The Netherlands, May 23, 2017 – ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company, today announced that an update of the results of a company-sponsored clinical Phase I/II trial in late-stage cervical cancer patients (ISA101-CervISA) will be presented at the 2017 ASCO Annual Meeting (June 2-6, 2017, Chicago, IL, USA).
A poster presentation will be held by Winald Gerritsen MD, PhD., one of the Principle Investigators of the CervISA study, on Thursday, June 3, 2017:
– Cornelis (“Kees”) Melief receives lifetime achievement award for his work as a leading immuno-hematologist
Leiden, The Netherlands, May 11, 2017 – ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company, today announced that its Chief Scientific Officer Prof. Cornelis (Kees) Melief has received the first ever lifetime achievement award granted by the Association for Cancer Immunotherapy CIMT for his pioneering research on cancer immunotherapy. The ceremony took place at this year´s 15th CIMT Anniversary Symposium in Mainz, Germany.
Kees Melief is professor emeritus at Leiden University Medical Center (LUMC) and the co-founder and CSO of ISA Pharmaceuticals. During his longstanding career, he has
– First data of phase I/II trial in HPV16-positive patients with late-stage cervical cancer
Leiden, The Netherlands, February 16, 2017 – ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company, today announced that results of a company-sponsored clinical Phase I/II trial in late-stage cervical cancer (ISA101-CervISA) will be presented at the inaugural ASCO-SITC congress on immuno-oncology (February 23-25, 2017, Orlando, FL, USA).
An oral and a poster presentation will be held by Prof. Cornelis Melief and Marij Welters, PhD, on Thursday, February 23, 2017:
“Poster Session A”: 11:30AM-1:00PM and 5:30PM-6:30PM (Cornelis Melief)