Clinical Studies

Several clinical trials of ISA Pharmaceuticals´ lead compound ISA101 are currently ongoing in HPV16-positive cancer indications, mostly in patients suffering from cervical cancer and head & neck cancer. Initial recruitment goals of the company-sponsored CervISA trial have been met. In preparation of the Phase 2 trial design, an extra arm has been included, which is assessing the safety of ISA101 vaccinations in combination with chemotherapy and bevacizumab, an inhibitor of angiogenesis. Moreover, the MD Anderson Cancer Center has conducted a clinical trial in the US in collaboration with Bristol Meyers Squibb and ISA Pharmaceuticals in incurable HPV16-positive cancer patients. In this study, patients were treated with a combination of ISA101 and Nivolumab. The safety and immunogenicity of ISA’s first SLP®-AMPLIVANT® conjugate ISA201 are currently validated in patients treated for HPV16-positive tumors or premalignant lesions.

If you would like to receive more information about the ongoing trials, please send an e-mail to info@isa-pharma.com.

 

Ongoing Trials:

ISA101

CervISA (Phase I/II)

Currently recruiting in Belgium and the Netherlands:

http://clinicaltrials.gov/show/NCT02128126

ISA101-CervISA_EN

 

ISA101+Nivolumab (Phase II)

MD Anderson Cancer Center in the United States of America

https://clinicaltrials.gov/ct2/show/NCT02426892

MDACC Study #2014-1047

ISA101-Nivolumab_EN_2

 

AIN (Phase I/II)

http://clinicaltrials.gov/ct2/show/NCT01923116

ISA101-VaccAIN_EN

 

ISA201

HESPECTA (Phase I/II)

Currently recruiting in the Netherlands at the Department of Clinical Oncology at Leiden University Medical Center:

http://clinicaltrials.gov/ct2/show/NCT02821494

ISA201-HESPECTA_EN

 

Completed Trials:

ISA101

ISA101_Completed Trials_EN