ISA Pharmaceuticals publiceert regelmatig haar bevindingen en gegevens in peer-reviewed tijdschriften, Hieronder vindt u een overzicht van de belangrijkste publicaties gegroepeerd op onderwerp:

SLP® Technologie

Belangrijkste Publicaties:

van der Sluis T, et al., Melief CJ, Arens R, van der Burg SH, van Hall T “Therapeutic peptide vaccine-induced CD8 T cells strongly modulate intratumoral macrophages required for tumor regression.” Can Immunol Res.; Sep;3(9):1042-51.

Gubin MM, et al.,  Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD. “Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.” Nature. 2014 Nov 27;515(7528):577-81.

Rosalia et al.; Melief CJ. “Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation.” Eur J Immunol.; 2013 Oct;43(10):2554-65. doi: 10.1002/eji.201343324. Epub 2013 Aug 5.


AMPLIVANT® Technologie

Belangrijkste Publicaties:

Zom GG, et al.  Melief CJ, van der Burg SH, Ossendorp F. “TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.Oncotarget. 2016 Aug;10.18632/oncotarget.11512.



Belangrijkste Publicaties:

Welters MJ, van der Sluis TC, van Meir H, et. al., Melief CJ, van der Burg SH. “Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses.” Sci Transl Med. 2016 Apr 13;8(334):334ra52.

van Poelgeest MI, et al., Melief CJ, van der Burg SH. “Vaccination against oncoproteins of HPV16 for non-invasive vulvar/vaginal lesions: lesion clearance is related to the strength of the T-cell response.” Clin Cancer Res 2016 May 15;22(10):2342-50

Van der Sluis TC, et al., Melief CJ. “Vaccine-induced Tumor Necrosis Factor producing T-cells synergize with cisplatin to promote tumor cell death.Clin Cancer Res. 2015 21(4): 781-794.

Kenter GG, et al., Melief CJ. “Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.N Engl J Med. 2009 Nov 5;361(19):1838-47.


Immunotherapie & Immunologische Expertise

Belangrijkste Publicaties:

van der Burg et al. SH, Melief CJ “Vaccines for established cancer: overcoming the challenges posed by immune evasion.” Nat Rev Cancer 2016,  219–233  (2016).

Melief CJ, et al., “Therapeutic Cancer Vaccines.” J Clin Invest 2015 125 (9):3401-12.